Date of Award

Spring 2001

Document Type



Life & Environmental Sciences

First Advisor

Jacqueline Brehe

Second Advisor

John Addis

Third Advisor

Gerald Shields


There have been several studies done on the effects of restraint stress and other physical and psychological stressors on the immune system. In addition, female sex hormones (estrogen and progesterone) are known immunomodulators as well as affectors of the neuroendocrine system. There is little research, however, tying the three systems together. In this study, I used a simple leukocyte differential count to quantitatively analyze the immune response to restraint stress and to see in what way estrogen and progesterone alter that response in the prepubescent laboratory mouse (Mus musculus). My data show that estrogen and progesterone drastically alter the cellular immune response to restraint stress.