Date of Award
Life & Environmental Sciences
Rev. Joseph Harrington
Enzyme Chemistry, for many years an important tool in food chemistry and Industrial and pharmaceutical industries, gains more and more importance for the clinical laboratory. One of the newer enzyme tests which can be a valuable aid to the physician in his diagnosis and prognosis is the determination of serum transaminases.
The transaminases are, as the name Indicates, "those of the many enzymes in animal tissue that transfer an amino group from one of several amino acids to its keto acid counterpart." A sample reaction is given below for glutamic oxaloacetic transaminase which catalyzes the transfer of an amino group, NHp, from aspartate to alpha-ketoglutarate and so transforms these compounds into oxaloacetate and glutamate.
Sechser, Carole, "Transaminase Activity In Humans" (1961). Life and Environmental Sciences Undergraduate Theses. 606.