Date of Award

Spring 1972

Document Type



Life & Environmental Sciences

First Advisor

James Manion

Second Advisor

Guido Bugni

Third Advisor

Vincent Palese Jr.


A chemical substance known as Actinomycin D has profound effects on living cells. Through extensive use of this chemical, biochemists have found a tool to explore the intricate secrets of the chemistry of living matter.

Actinomycin D (AMD) is a chemical substance called an antibiotic. Antibiotics are chemicals produced by living microorganisms that have the ability to inhibit growth or to destroy bacteria and other microorganisms. The actinomycins are a family of antibiotics with antitumor activity that are produced by Streptomyces antlbioticus (Abraham, 1959) and other species of Streptomyces.