Date of Award

Spring 1965

Document Type



Life & Environmental Sciences


In order to fully understand DNA synthesis in the regenerating liver, one must understand liver regeneration as a whole.

Liver generation can therefore be divided into two stages. The first stage, lasting approximately one week, consists of rapid restoration of the hepatic cells. Individual hepatocytes are enlarged and undergo rapid mitosis. The second stage, lasting from seven days to twenty-eight days, is characterized by increasing liver fluids which brings the liver to its original weight. The first stage of liver regeneration will be extensively covered in this paper with emphasis on DNA synthesis.