Date of Award

Spring 1975

Document Type



Life & Environmental Sciences

First Advisor

Jean Smith

Second Advisor

James Manion

Third Advisor

Guido Bugni


Investigations Into the effects of nicotine on athero- genesis in mice were made. Four groups of mice were fed different diets for a period of four weeks and then sacrificed. Microscopic examination of the descending thoracic aorta revealed no presence of lesions. Analysis of test on the blood demonstrated lower levels of serum cholesterol in nicotine administered mice. Theories on nicotine and cholesterol involvement are discussed along with current ideas on the normal aortic aging process, the atherosclerotic process, and useful prophylactic measures.