Date of Award

Spring 1978

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

James Manion

Second Advisor

John Christenson

Third Advisor

Guido Bugni

Abstract

Cytogenetic analysis of mouse bone marrow chromosomes after treatment of the experimental animals with triethylenemelamine (TEM) revealed, an overall increase in the number of chromosome aberrations A dose-response curve for TEM is given and its significance discussed. An unexpected increase in the number of rings as well as a relatively constant value for the aberrations/oell ratio in each of three dosage groups (and control) were observed. Possible mechanisms are given attention.

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