Date of Award

Spring 1979

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

James Manion

Second Advisor

Rev. Joseph Harrington

Third Advisor

Lindsay Hess

Abstract

Bone regeneration was assessed in albino laboratory rats in terms of the length of growth at the sites of regeneration. Bone fragments of 2.5-5.0 mm were excised from the midsections of the fibulae. The experiment ran for twenty days after surgery, at which time the animals were sacrificed for closer analysis. Six rats were allowed to regenerate under normal conditions. The second group of six rats were allowed to regenerate under the influence of a pulsing stimulus of 22 amps at a frequency of 5-6 Hz, at a duration of 0.1 seconds. This stimulus was provided by an integrated-circuit 3-volt battery component affixed to the back of the animals (via a backpack-harness) via wires under the skin to the rat's lower leg. Rat food and water were given ad lib as needed. Statistical analysis shows that regeneration occurred at a faster rate in those specimens receiving electrical stimulation.

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