Date of Award

Spring 1979

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

James Manion

Second Advisor

John Christenson

Third Advisor

Gary Hoovestal

Abstract

Twelve pregnant Swiss-Webster mice were injected, intraperitoneally with Kepone on days 7-16 of gestation. Four mice received 0.1 ml of 2.5 mg of Kepone dissolved in 1.0 ml of sesame oil; four mice received 0.1 ml of 5.0 mg of Kepone dissolved in 1.0 ml of sesame oil; and the last four mice received only 0.1 ml of sesame oil. Litter size was reduced for those injected with Kepone. The male test progeny had a more rapid initial testicular development than the controls, but this slowed until at maturation, testicular development and histology were the same as the controls. The female test progeny had decreased corpus luteum formation, and a greater number and size of developing follicles than the controls; although both female test groups showed these abnormalities, only those receiving 5.0 mg of Kepone were significantly affected.

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