Date of Award

Spring 1979

Document Type



Life & Environmental Sciences

First Advisor

Philip Pallister

Second Advisor

James Manion

Third Advisor

John Christenson


The antiepileptic drug sodium valproate was studied in 19 epileptic patients with uncontrolled seizures of a generalized or partial type. Two-thirds of the patients experienced a reduction in seizure fre uency ranging from 33 to 100%. Adverse effects occurred in 7 (37%) patients and in 4 (21%) the drug had to be discontinued. The most serious adverse effects were platelet reduction and weight gain. Minor adverse effects (e.g. nausea, hair loss, SGOT elevation, ALKOP4 elevation) were always transient.