Date of Award

Spring 1980

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

James Manion

Second Advisor

Guido Bugni

Third Advisor

Rev. Joseph Harrington

Abstract

The uptake of dehydroascorbate (DHA) was studied in both diabetic and non-diabetic polymorphonuclear leucocytes (PMN). The mean uptake of DHA was found to be lower in the diabetic than non-diabetic group. The uptake of DHA was also lower when PMN were incubated in a final concentration of 3 mg/ml glucose instead of 1 mg/ml glucose. There appears to be an inverse relationship between glucose concentration and DHA uptake in PMN; that is, when glucose levels are increased, DHA uptake is decreased. This may cause the accumulation of DHA in diabetic plasma and contribute to the complications of diabetes.

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