Date of Award
Life & Environmental Sciences
Rev. Joseph Harrington
The uptake of dehydroascorbate (DHA) was studied in both diabetic and non-diabetic polymorphonuclear leucocytes (PMN). The mean uptake of DHA was found to be lower in the diabetic than non-diabetic group. The uptake of DHA was also lower when PMN were incubated in a final concentration of 3 mg/ml glucose instead of 1 mg/ml glucose. There appears to be an inverse relationship between glucose concentration and DHA uptake in PMN; that is, when glucose levels are increased, DHA uptake is decreased. This may cause the accumulation of DHA in diabetic plasma and contribute to the complications of diabetes.
Hegewald, Michael, "The Uptake Of Dehydroascorbate In The Polymorphonuclear Leucocytes Of The Diabetic Vs Non-Diabetic Individual" (1980). Life and Environmental Sciences Undergraduate Theses. 480.