Date of Award

Spring 1980

Document Type



Life & Environmental Sciences

First Advisor

James Manion

Second Advisor

Rev. Joseph Harrington

Third Advisor

Guido Bugni


Fifteen eight-week-old female Sprague Dawley rats were used to determine the effects of thyrocalcitonin on osteogenic regeneration. Bone fragments of 2.8-5.3 mm were extracted from the mid-shaft of the right hind fibulae. Following surgery, seven control animals were administered saline for twenty consecutive days, whereas eight experimental animals were injected subcutaneously with 7.5 mMRC/200 g body wt of thyrocalcitonin for twenty consecutive days. After experimentation was complete, the rats were sacrificed and morphological observations were made to quantify the lengths of fibulae gaps before and after treatment. Statistical analysis indicates that bone regeneration occurs at a faster rate in those animals receiving thyrocalcitonin.

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