Date of Award

Spring 1982

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

James Manion

Second Advisor

Arthur Westwell

Third Advisor

Rev. Eugene Peoples

Abstract

A variety of samples isolated, from four types of sources (sponges, tunicates, algae, and cranberries) was tested for mutagenic effects. Established procedures used for mutagenic detection employed here consisted of a) genetic toxicology on Escherichia coli, b) Ames Spot Test, and c) the Ames Test. Of the twenty-two samples tested, seven showed some level of genetic toxicity on repair tests. Of these seven, three ( 1) a methyl hydroxide extract from the calcareous sponge, Leucetia microraphis, 2) an ethylacetate extract from the leaves of cranberries, and 3) an ether extract from Leucetia microraphis) showed significant or close to significant levels of mutagenicity in reversion studies.

Included in

Toxicology Commons

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