Date of Award

Spring 1985

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

John Christenson

Second Advisor

James Manion

Third Advisor

Douglas Flippen

Abstract

Common electophoretic and electroblot methods were used to differentiate between possibly different epitopes on digested whole pertussigen. In this study, S-l subunit specific monoclonal antibodies were used. The results of these tests indicate that these monoclonal antibodies react with the same antigenic region and do not distinguish between any other epitopes that may be present on the S-l subunit. Further development and testing of monoclonal antibodies against the various subunits of pertussigen will be required to elucidate the nature and presence of other epitopes of pertussigen.

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