Date of Award

Spring 1985

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

Fr. Joseph Harrington

Second Advisor

Jean Smith

Third Advisor

Philip Wittman

Abstract

Friend virus (FV) is a murine leukemia virus. Previous studies have indicated that a profound humoral immunosuppression accompanies the erythroleukemia caused by FV. The presence of antibodies to Friend virus and sheep erythrocytes in the plasma of erythroleukemic mice which are capable of mounting an immune response to FV was tested using agglutination and cell binding assays in order to determine if humoral immunosuppression exists in the bloodstream. Friend virus-infected mice exhibited the same antibody response as normal mice, so no immunosuppression was discovered. The immunosuppressive effects of the disease are under genetic control. A better understanding of immunosuppression effects of this disease leads to a better understanding of leukemia and its genetic control.

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