Date of Award

Spring 1988

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

Fr. Joseph Harrington

Second Advisor

John Christenson

Third Advisor

Robert Swartout

Abstract

The effect of implanted pheochromocytoma on (1) blood pressure, (2) catecholamine concentration, and (3) T4 and T8 lymphocyte subsets in the rat (New England Deaconess Hospital strain) was studied. Blood pressure increased significantly. Catecholamine concentrations rose greatly after tumor implant, with dopamine showing the greatest increase. T4 percentages decreased slightly as compared to pre-implant percentages. T8 results could be divided into two subsets based on a definite increase or a definite decrease from pre-implant percentages. Finally, rats that showed an increase of T8 cells had significantly greater concentrations of dopamine (and, to a lesser extent, epinephrine and norepinephrine) than those with a decrease of T8 cells.

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