Date of Award

Spring 1988

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

John Addis

Second Advisor

Guido Bugni

Third Advisor

Marilyn Schendel

Abstract

In this study several male volunteers were infected with piliated gonococci expressing none of the pH proteins. Urine samples were collected from the patients twice daily until the patient developed clinical symptoms of gonorrhea. The samples from each volunteer were then analyzed in order to characterize how pII expression varied while being present in a human host. Pili were also examined for diferences in molecular weight. My role was to study the reisolated gonococci from patient 016. Pili were examined by epitope mapping, and the sequences of four pilin genes taken from the last urine sample were determined.

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