Date of Award

Spring 1989

Document Type



Life & Environmental Sciences

First Advisor

Juergen Bertram

Second Advisor

John Addis

Third Advisor

Carol Baldwin


Four patients, two with Idiopathic Thrombocytopenic Purpura, one with advanced Astrocytoma, and one with Systemic Lupus Neutropenia, were treated with the Prosorba® Immunoadsorption Column on an out-patient basis. A complete response was observed in one of the ITP patients while a partial remission occurred in the other patient with ITP. Absolute neutrophil counts increased in the Systemic Lupus Neutropenia patient indicating response to therapy, and CT scans and subjective improvements indicate successful therapy in the astrocytoma patient. Systemic reactions occurred in 3.4% of the treatments. Protein A Immunoadsorption therapy thus was safe and effective in the treated patients.