Date of Award

Spring 1990

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

John Addis

Second Advisor

Rev. Joseph Harrington

Third Advisor

Robert Swartout

Abstract

The activity of the duodenal disaccharidase, maltase, from the time of duodenal ulcer induction in the mouse to 49 days beyond, was investigated. tor Cysteamine-HCl, a duodenal specific ulcerogen for both the rat and mouse, was used to generate an animal model of the human disease. The activity of the disaccharidase enzyme varied significantly throughout the 49 day study, and it varied in correlation with previously documented morphological changes. The activity dropped to a low point by the fourth day following cysteamine administration. Between day 4 and day 20, the activity of duodenal maltase continued to increase and then leveled off and resembled maltase activity in the normal duodenum.

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