Date of Award
Life & Environmental Sciences
Rev. Joseph Harrington
The process of metastasis requires tumor cells to migrate through the basement membrane which consists of laminin, a glycoprotein which promotes the adhesion of HT-1080 fibrosarcoma cells. The present study was designed to test four peptides, corresponding to short sequences of the intact laminin molecule, for cell adhesion-promoting activity. By using three different cell migration assays, the four peptides were monitored for their cell adhesive-promoting activity. Results were obtained showing some cell adhesive-promoting activity from all four peptides.
Freitag, Corby, "Identification of Laminin Domains That Promote Tumor Cell Adhesion" (1991). Life and Environmental Sciences Undergraduate Theses. 298.