Date of Award

Spring 1995

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

Marilyn Schendel

Second Advisor

John Addis

Third Advisor

Jean Priest

Abstract

The purpose of this study was to further the understanding of the causes of triploidy in spontaneous abortions in humans. Triploidy is a chromosomal aberration that can be caused by several erroneous occurrences during gamete formation or fertilization. In the present study, reports that involve cases of triploidy from prenatal genetics laboratories in the United States were collected. The emphasis was put on recurrent triploidy. The percentage of triploidy cases out of all triploid spontaneous abortions, as well as the percentages of XXX, XXY, and XYY cases, respectively, have been determined. Based on literature review, possible etiology of triploidy was established. Case reports of patients from Shodair Hospital in Helena, MT, who had recurrent spontaneous abortions caused by triploidy, were included.

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