Date of Award
Spring 2004
Document Type
Thesis
Department
Life & Environmental Sciences
First Advisor
John Addis
Second Advisor
Marilyn Schendel
Third Advisor
Gerald Shields
Abstract
In D. melanogaster, CycE and E2F1 are critical proteins in endocycle control. It is known that both of these proteins are required for endocycling and that cycE mRNA and protein oscillate in endoreduplicating tissues (ERT’s). The mechanism of endocycle regulation by E2F1 through CycE, however, has not been elucidated. Here, I implicate E2F1 protein oscillation in the fluctuation of two of its specific target genes, cycE and rnr2, which is then responsible for the G-S transition ofDrosophila ERT’s. The results also suggest that E2F1 control of S phase initiation within the endocycling cell is dependent on nutritional inputs.
Recommended Citation
Black, Lindsay, "The Role of E2F1 in Endocycle Regulation" (2004). Life and Environmental Sciences Undergraduate Theses. 224.
https://scholars.carroll.edu/lifesci_theses/224