Date of Award

Spring 2006

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

Sam Alvey

Second Advisor

Ron Wilde

Third Advisor

Murphy Fox

Abstract

Cancer is the second leading cause of death in the United States. Prostate cancer affects one in seven men in the United States. Thus, prostate cancer provides a very serious healthy threat to men in the United States. Unfortunately, not much is known as to how normal prostate cells are transformed into a cancerous state, or how once transformed remain in the cancerous state. A study preformed by Porkka et. al in 2002 revealed that Elongin C is over expressed in prostate cancer cell lines. I hypothesize that over expression of Elongin C could inappropriately stabilize or destabilize key proteins involved in cell regulation leading to the mutation and or proliferation of cancerous cells. Through the use of a two-hybrid screening process I have identified four proteins within the prostate cell that interact with Elongin C.

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