Date of Award

Spring 2015

Document Type

Thesis

Department

Life & Environmental Sciences

Abstract

Prion diseases are very rare, neurodegenerative diseases caused by misfolding of the Prion protein. The pathologies created by the misfolded protein are remarkably similar to those of Alzheimer’s disease. This paper provides a comprehensive study of the genomic and proteomic similarities between Prion proteins and several proteins implicated in Alzheimer’s disease (AD). While genomic similarity has been proven, studies are unclear as to whether any genomic mutations in PRNP affect the progression of AD. Studies have definitively proven that Prion protein interacts on a molecular level with several proteins implicated in AD. These interactions require further study to definitively prove whether they speed or slow AD progression, but current evidence indicates that Prion protein interaction will lead to faster progression of AD in vitro.

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