Date of Award

Spring 1997

Document Type

Thesis

Department

Life & Environmental Sciences

First Advisor

Marilyn Schendel

Second Advisor

Grant Hokit

Third Advisor

Mary Haag

Abstract

An R-banding protocol was developed in order to study the X-inactivation pattern of a patient with a duplicated X chromosome. R-banding was used because it results in the differential banding of the active and inactive X chromosome due to differing replication patterns with the active X being early replicating and the inactive X being late replicating. The results demonstrate that the patient’s normal X chromosome was early replicating as well as the duplicated region of the abnormal X chromosome. This suggests that the observed phenotype is a result of incomplete inactivation of the duplicated X chromosome.

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