Synthesis of CifiDABCO and mannose co-functionalized G(4)-PAMAM dendrimer for use in antibiotics

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Authors
VanKoten, Harrison
Advisor
Editor
Date of Issue
2010-04-01
Subject Keywords
antibiotic, antimicrobial
Publisher
Citation
Series/Report No.
item.page.identifier
Title
Synthesis of CifiDABCO and mannose co-functionalized G(4)-PAMAM dendrimer for use in antibiotics
Other Titles
Type
thesis
Description
Abstract
Synthesis of C16DABCO and mannose co-functionalized G(4)-PAMAM dendrimer is expected to yield a useful antimicrobial that is effective in binding to mannose specific lectins on bacterial fimbriae. Thus far, mannose has been attached to the dendrimer with near complete functionalization. C16DABCO and mannose cofunctionalized G(4)-PAMAM dendrimer have been synthesized, but not in sufficient quantities to allow examination of its the antibacterial properties. Future work includes optimizing the final synthesis and performing toxicity studies.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Chemistry & Physics