Uniparental Disomy Studies By PCR Analysis

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Authors
Paynich, Joshua
Advisor
Marilyn Schendel
John Addis
Ron Stottlemyer
Editor
Date of Issue
1996-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
Uniparental Disomy Studies By PCR Analysis
Other Titles
Type
thesis
Description
Abstract
Uniparental disomy is a condition that results in many genetic anomalies. The condition involves an individual who has inherited both members of a homologous pair of chromosomes from one parent, while all other chromosome pairs come from biparental inheritance. That is, each parent contributes one chromosome to each homologous pair. The intent of the study was to find individuals with this condition. To test for uniparental disomy PCR technology was used to amplify regions of polymorphic microsatellite repeats. This PCR technique allows the experimenter to determine the origin of the child's chromosomes. Two individuals suspected of uniparental disomy were tested. The result was negative for uniparental disomy in both cases.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences