Reversal Of Multidrug Resistance Using Cyclosporin A

Loading...
Thumbnail Image
Authors
Manley, Sara
Advisor
John Christenson
Rev. Joseph Harrington
Rev. J. Eugene Peoples
Editor
Date of Issue
1989-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
Reversal Of Multidrug Resistance Using Cyclosporin A
Other Titles
Type
thesis
Description
Abstract
Multidrug resistance is a phenomenon which occurs in cancer cells. These cells become resistant to the drug of treatment as well as resistant to other unrelated chemotherapeutic drugs. Previous studies have shown that calmodulin inhibitors and calcium channel blockers are able to reverse resistance in these cells when used in conjunction with the chemotherapeutic drug. In this study, the ability of the immunosuppressive drug, cyclosporin A to overcome cellular resistance to the chemotherapeutic drug vincristine was analyzed. The Chinese hamster cell line, DC-3F and its multidrug resistant variant, DC-3F/VCRd-5L were used. Analysis revealed that cyclosporin A caused complete reversal of multidrug resistance in resistant cells and caused increased sensitivity to vincristine in sensitive cells.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences