Global metabolic profiling of human joint fluid following a second ACL tear: A case report

carrollscholars.legacy.contextkey15998154
carrollscholars.legacy.itemurlhttps://scholars.carroll.edu/healthsci_theses/13
carrollscholars.object.degreeBachelor's
carrollscholars.object.departmentHealth Sciences
carrollscholars.object.disciplinesBiochemical Phenomena, Metabolism, and Nutrition; Medical Biochemistry; Musculoskeletal, Neural, and Ocular Physiology
carrollscholars.object.seasonWinter
dc.contributor.advisorAlyssa Hahn
dc.contributor.advisorBrandon Sheafor
dc.contributor.advisorKelly Parsley
dc.contributor.authorStarke, Jenna
dc.date.accessioned2020-04-30T09:56:39Z
dc.date.available2020-04-30T09:56:39Z
dc.date.embargo12/31/1899 0:00
dc.date.issued2019-01-01
dc.description.abstractObjectives: The objective of this study was to investigate the acute metabolic response to injury using global, or untargeted, metabolic profiling. The purpose was to better understand the acute response to injury following a second traumatic joint injury. Methods: This study is a case report of a patient who had sustained two separate ACL tears in the same knee years apart. We extracted metabolites from healthy synovial fluid and human joint fluid following the patient’s second ACL tear and analyzed the metabolite extracts using liquid chromatography-mass spectrometry (LC-MS)-based global metabolic profiling. Results: We identified 1241 unique metabolite features in injured SF compared to healthy SF (Student’s t-test: FDR-adjusted p-value
dc.identifier.urihttps://scholars.carroll.edu/handle/20.500.12647/2488
dc.subjectACL tear, metabolic profiling
dc.titleGlobal metabolic profiling of human joint fluid following a second ACL tear: A case report
dc.typethesis
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
StarkeJ_2019_Final.pdf
Size:
892.01 KB
Format:
Adobe Portable Document Format