Site Specific Photoinitiated Release of Bromothymol Blue
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Authors
Hoffman, Alexander
Stewart, Taryn
Brady, Keaton
Mundel, Samantha
Date of Issue
2019-04-25
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Abstract
Delivery of pharmaceutical drugs to specific sites of the body would be beneficial for the treatment of cancer and other major ailments which affect singular areas of the body. There are promising possibilities being studied to determine their efficacy. Here is presented the investigation of the photoinitiated release of an indicator, acting as a drug, from a vesicle into an environment containing a reactant. In this experiment, spiropyran was integrated into Dipalmitoylphosphatitylcholine (DMPC) and 1’,3’,3’-Trimethylspiro[chromene-2,2’-indoline] (spiropyran) are the components of the carrier vesicles that surround bromothymol blue (BTB) in the sodium bicarbonate solution. Spiropyran is a photochromic compound that changes structure when exposed to UV-light.1