Synthesis of 3-oxyangeloyl Trematone

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Authors
Dailey, Orrin
Advisor
Pharr, Caroline
Editor
Date of Issue
2022
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Title
Synthesis of 3-oxyangeloyl Trematone
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Presentation
Description
This is a presentation on the total synthesis of 3-oxyangeloyl trematone. A 5 step synthesis has been proposed and is being tested in the Integrated Lab
Abstract
The natural product 3-oxyangeloyl-tremetone has been found to be a potent analgesic. Analgesic compounds have pain killing properties, and are widely used in pain management. This compound can be found in the plant Parastephia lepidophylla in Chile. Extraction of natural products can be expensive and time consuming and is not feasible for large scale production of pharmaceuticals. As a result, a five step synthesis to form the compound of interest from cost effective and readily available starting materials has been proposed. Starting with anisole and acetyl chloride, a Friedel-Crafts acylation was performed. This first step has been completed and the product has been isolated and purified. Synthesis of the next intermediate molecule, from step two, is underway.
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Chemistry