Studies Towards the Synthesis of Novel Oxadiazole Derivatives for Antibiotic Screening Against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.

carrollscholars.object.coursenameMicrobiology, Integrated Lab I Laben_US
carrollscholars.object.coursenumberBI-305, CH-411en_US
carrollscholars.object.departmentChemistryen_US
carrollscholars.object.departmentBiologyen_US
carrollscholars.object.departmentBiochemistryen_US
carrollscholars.object.majorBiochemistryen_US
carrollscholars.object.majorBiologyen_US
dc.contributor.advisorHitt, David
dc.contributor.advisorMcHugh, Theresa
dc.contributor.authorHewes, Patrick
dc.contributor.authorHenderson, Michael
dc.date.accessioned2021-04-21T03:29:35Z
dc.date.available2021-04-21T03:29:35Z
dc.date.issued2021-04-16
dc.descriptionUndergraduate work by Michael Henderson and Patrick Hewes to synthesize a novel diazole antibiotic, and to standardize Kirby Bauer and MIC assays using the tools and resources available at Carroll College.en_US
dc.description.abstractBacterial antibiotic resistance continues to render current pharmaceutical drugs ineffective at preventing the growth of hard-to-treat bacterial strains. Persistent under current treatments, methicillin-resistant Staphylococcus aureus (MRSA) has presented as a major issue on a global level, impacting increasing numbers of patients in clinical settings (O’Daniel, et. al).1 Hypothesis: Treatment of an oxadiazole class and selected control antibiotics to bacterial strains will exhibit a significant drop in growth. Our approach: Determination of antibacterial properties-effective concentrations was achieved by Kirby-Bauer disk diffusion and Minimum Inhibition Concentration assay(s) (MIC). Results: We report an unsuccessful attempt to synthesize a novel oxadiazole antibiotic, but present promise in standardizing biological assays using three control antibiotics. In conclusion: the data indicates that Penicillin, Vancomycin, and Gentamicin display antibacterial properties against the growth of Escherichia-coli, Staphylococcus aureus, and Pseudomonas aeruginosa. We speculate, with this report, further antibiotic classification at Carroll College is possible with the standardized procedure, once novel antibiotics are synthesized.en_US
dc.identifier.urihttps://scholars.carroll.edu/handle/20.500.12647/10380
dc.identifier.urihttps://www.youtube.com/watch?v=f3n0mW4KVDg
dc.language.isoenen_US
dc.titleStudies Towards the Synthesis of Novel Oxadiazole Derivatives for Antibiotic Screening Against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.en_US
dc.typePresentationen_US
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