A Screening Of Crude Organic Extracts For Mutagenicity Using Repair And Reversion Methods
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Authors
Harrington, Brian
Advisor
James Manion
Arthur Westwell
Rev. Eugene Peoples
Arthur Westwell
Rev. Eugene Peoples
Editor
Date of Issue
1982-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
A Screening Of Crude Organic Extracts For Mutagenicity Using Repair And Reversion Methods
Other Titles
Type
thesis
Description
Abstract
A variety of samples isolated, from four types of sources (sponges, tunicates, algae, and cranberries) was tested for mutagenic effects. Established procedures used for mutagenic detection employed here consisted of a) genetic toxicology on Escherichia coli, b) Ames Spot Test, and c) the Ames Test. Of the twenty-two samples tested, seven showed some level of genetic toxicity on repair tests. Of these seven, three ( 1) a methyl hydroxide extract from the calcareous sponge, Leucetia microraphis, 2) an ethylacetate extract from the leaves of cranberries, and 3) an ether extract from Leucetia microraphis) showed significant or close to significant levels of mutagenicity in reversion studies.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences