Chronic Wound Treatment Using Mesenchymal Stem Cells: A Systematic Review

Abstract

Objective: To review current literature about the effectiveness of mesenchymal stem cell treatment on chronic wounds. Methods: Literature was gathered through PubMed, CINHAL, and Google Scholar and assessed for the effectiveness of mesenchymal stem cell (MSC) treatment on chronic wounds. Results: The majority of the literature supported the stance that MSC interventions have a favorable effect on patients with chronic skin wounds. Conclusions: MSC treatment shows promising results for patients with chronic skin wounds. The treatment mentioned in this review should be researched further to discover the best dosage and further studies should examine the safety of MSCs. When different dosages were directly compared, studies didn’t identify a preferred dosage for best improving skin dermis in patients with chronic skin wounds. Keywords: Mesenchymal stem cells; chronic wounds; psoriasis; atopic dermatitis; diabetes mellitus; acute skin wounds; recessive dystrophic epidermolysis bullosa.