The Effects On The Reproductive Organs Of Mice Following In Utero Exposure To Kepone
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Authors
Lemire, Shull
Advisor
James Manion
John Christenson
Gary Hoovestal
John Christenson
Gary Hoovestal
Editor
Date of Issue
1979-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
The Effects On The Reproductive Organs Of Mice Following In Utero Exposure To Kepone
Other Titles
Type
thesis
Description
Abstract
Twelve pregnant Swiss-Webster mice were injected, intraperitoneally with Kepone on days 7-16 of gestation. Four mice received 0.1 ml of 2.5 mg of Kepone dissolved in 1.0 ml of sesame oil; four mice received 0.1 ml of 5.0 mg of Kepone dissolved in 1.0 ml of sesame oil; and the last four mice received only 0.1 ml of sesame oil. Litter size was reduced for those injected with Kepone. The male test progeny had a more rapid initial testicular development than the controls, but this slowed until at maturation, testicular development and histology were the same as the controls. The female test progeny had decreased corpus luteum formation, and a greater number and size of developing follicles than the controls; although both female test groups showed these abnormalities, only those receiving 5.0 mg of Kepone were significantly affected.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences