The Effect of Advanced Glycation End Product Inhibition on the Development of Diabetic Encephalopathy in Rats
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Authors
Gay, Nathanael
Date of Issue
2007-04-01
Type
thesis
Language
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Abstract
Advanced glycation end product (AGE) endogenous proliferation has been identified as a result of long term hyperglycemia associated with diabetes metillus. These products have been linked to various problems of aging and diabetes. This study used diabetic and non-diabetic rats. Each group received either the placebo, or the AGE inhibitor, aminoguanidine. The animals were then cognitively evaluated after eight weeks. I hypothesized that, diabetic rats receiving aminoguanidine would show reduced cognitive decline as compared with diabetic rats not receiving aminoguanidine. My observations support my hypothesis.