Liposomes vs Lipid Nanoparticle (LNP) Antibiotic Entrapment Efficiency Utilizing Fluorescein Dye

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Authors
Henderson, Michael
Advisor
Rowley, John
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Date of Issue
2021-04-14
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Title
Liposomes vs Lipid Nanoparticle (LNP) Antibiotic Entrapment Efficiency Utilizing Fluorescein Dye
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Abstract
A wide variety of techniques are available for small-scale drug carriers to deliver pharmaceutically active drug compounds into target cells. Liposomes are frequently postulated as efficient pharmaceutical carriers to deliver drugs that have poor water solubility. To entrap these active drug components into carriers with even higher efficiency and consistency, we hypothesized that the use of lipid nanoparticle (LNP)s would provide pristine environments to encapsulate pharmaceuticals based on their characteristics. Herein we attempt to quantitatively compare the relative success and efficiency of nanoparticle encapsulation between liposomes and LNPs through capture and release of a fluorescent dye. It was seen the selected dye was heat sensitive, though the data showed promise for LNP encapsulation.
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Chemistry Department