Hemoglobin Synthesis In Mice Doubly Heterozygous For Alpha And Beta Thalassemia

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Authors
Smith, Eric
Advisor
John Christenson
James Manion
Rev. Robert McCarthy
Editor
Date of Issue
1984-04-01
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Publisher
Citation
Series/Report No.
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Title
Hemoglobin Synthesis In Mice Doubly Heterozygous For Alpha And Beta Thalassemia
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Type
thesis
Description
Abstract
The extent of imbalance between the synthesis rate of «-globin polypeptide chains relative to B-globin chains in thalassemic mice is one of the major factors in determining the pathophysiology of thalassemia. Mice doubly heterozygous for both a mutant ®<-thalassemic chromosome and a /?-thalassemic chromosome exhibited a hypochromic, microcytic anemia with mild reticulocytosis and erythrocytosis. However, the erythrocytes of these mice displayed few signs of hemolysis, or poikilocytosis, and did not contain visible inclusion bodies. Analysis of the relative rates of globin chain syntheses in vitro by ^H-leucine incorporation revealed the
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences