The Role Of Prostaglandin-H Synthase In Germ Cell Mutagenesis
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Authors
Berkram, Jennifer
Date of Issue
1987-04-01
Type
thesis
Language
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Abstract
The role of prostaglandin-H synthase in the activation of dimethylnitrosamine to induce genetic mutations was studied. The test organisms used were two strains of Drosophila melanoaaster. A comparison was made to estimate the proportions of mutations resulting from dimethylnitrosamine-demethylase activation of dimethylnitrosamine and from prostaglandin-H synthase activation of the chemical. Sex-linked recessive lethal tests were performed and statistically evaluated to determine whether or not prostaglandin-H synthase could serve as an alternate or major pathway in metabolism of the chemical dimethylnitrosamine. The results of these tests indicate that prostaglandin-H synthase is probably not involved in the mutation process.