Identification of Laminin Domains That Promote Tumor Cell Adhesion
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Authors
Freitag, Corby
Date of Issue
1991-04-01
Type
thesis
Language
Subject Keywords
Other Titles
Abstract
The process of metastasis requires tumor cells to migrate through the basement membrane which consists of laminin, a glycoprotein which promotes the adhesion of HT-1080 fibrosarcoma cells. The present study was designed to test four peptides, corresponding to short sequences of the intact laminin molecule, for cell adhesion-promoting activity. By using three different cell migration assays, the four peptides were monitored for their cell adhesive-promoting activity. Results were obtained showing some cell adhesive-promoting activity from all four peptides.