Differential Expression of Mitochondrial Proteins in Alzheimer’s Disease Patients Compared to Age-Matched Controls
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Authors
Flaherty, Erin
Advisor
Marilyn Schendel
John Addis
Joan Stottlemyer
John Addis
Joan Stottlemyer
Editor
Date of Issue
2004-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
Differential Expression of Mitochondrial Proteins in Alzheimer’s Disease Patients Compared to Age-Matched Controls
Other Titles
Type
thesis
Description
Abstract
To date, the pathology of Alzheimer’s remains unknown, and many researchers have focused on the mitochondria as playing a significant role in its progression. In earlier studies, it was found that mRNA levels of mitochondrial proteins of Alzheimer’s Disease patients were altered in mouse and human models. Additional research is warranted to determine if the mRNA differences are translated to the protein level. It has been shown that mitochondrial genes are differentially expressed in Alzheimer’s patients when compared to age-matched controls. I propose the levels of the translated gene product will also be altered. To test this hypothesis a proteomic approach utilizing 2-D electrophoresis to separate mitochondrial proteins and compare expression between diseased and control samples was used. These results are preliminary and further trials will cement the results.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences