Exploring GluR2-Interacting Proteins in Caenorhabditis elegans

Loading...
Thumbnail Image
Authors
Brothers, John
Advisor
Stephanie Otto-Hitt
William Parsons
Brandon Sheafor
Editor
Date of Issue
2016-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
Exploring GluR2-Interacting Proteins in Caenorhabditis elegans
Other Titles
Type
thesis
Description
Abstract
The expression of ?-3-hydroxy-5-Methlisoxaole-4-Propionic Acid Receptors (AMPARs) on the post-synaptic region of a neuron has direct impacts on many physiological functions of the brain, including learning and memory. Because AMPARs are Qirst assembled in the endoplasmic reticulum and later transported to the post-synaptic region of a neuron, understanding the mechanisms involved in AMPAR-trafQicking is crucial to understanding a variety of neuronal functions. The goal of this research was to investigate the role of the putative AMPAR-trafQicking proteins DLI-1, VDAC-1, SVOP-2, and DCN-2 on AMPAR-mediated behavior in the nematode Caenorhabditis elegans (C. elegans). Unfortunately, several technical issues prevented development of the constructs and behavioral assays needed to fully accomplish the goals of this study. Therefore, I am unable to discourse on the roles of DLI-1, VDAC-1, SVOP-2, and DCN-2 in AMPAR-mediated behavior in C. elegans.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences