Neurological Effects of Chlorpyrifos on Prenatally-Exposed Rats

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Authors
Denning, Kyle
Advisor
Jacqueline Brehe
Jennifer Glowienka
Murphy Fox
Editor
Date of Issue
2008-04-01
Subject Keywords
autism, chlorpyrifos
Publisher
Citation
Series/Report No.
item.page.identifier
Title
Neurological Effects of Chlorpyrifos on Prenatally-Exposed Rats
Other Titles
Type
thesis
Description
Abstract
Though extensively documented, autism is still poorly understood. Possible factors include prenatal or neonatal chemical exposure that causes declined synaptic transmission. One chemical, the pesticide known as chlorpyrifos, has been shown to cause anatomical differences in the areas of rats’ brains that are linked to behavioral symptoms closely related to autism. With the knowledge of the increased susceptibility ofmales to prenatal drug exposure, it was hypothesized that male rats exposed to chlorpyrifos before birth would exhibit such symptoms. Two tests, an elevated plus maze and a Morris water maze, were used to test anxiety and cognition, respectively. Anxiety tests yielded no differences between rats prenatally exposed to the chemical, or between males and females. Similarly, cognition tests showed no such correlations. Though these results suggest no apparent connection between chlorpyrifos and autism-like behavior, it is still unclear whether the rats experienced internal anatomical change due to their exposure. Used as a pilot study, this experiment could be coupled with a cellular analysis to fully illustrate the effects of chlorpyrifos.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences