Optimization of Lactose-Functionalized Poly(amidoamine) Dendrimer Synthesis

carrollscholars.object.coursenameOrganic Chemistry Research Internshipen_US
carrollscholars.object.coursenumberCH 425en_US
carrollscholars.object.departmentChemistryen_US
carrollscholars.object.majorBiochemistry/Molecular Biologyen_US
dc.contributor.advisorCloninger, Mary
dc.contributor.authorField, Cameren
dc.date.accessioned2022-04-22T19:25:10Z
dc.date.available2022-04-22T19:25:10Z
dc.date.issued2022
dc.description.abstractGlycopolymers have been previously shown to regulate multivalent galectin-3 mediated processes in cancer progression including in vitro homotypic cancer cellular aggregation/tumor formation, cancer cellular migration, angiogenesis, proliferation, and apoptosis. The objective of this research is to develop multivalent synthetic frameworks that bind to galectin-3 and inhibit its anti-apoptotic biochemical pathway in SKOV-3 and OVCAR-3 ovarian cancer cell lines, thus preventing platinum chemotherapy agent resistance. Herein is the reported data for designing a high-yielding synthesis of lactose-functionalized poly(amidoamine) dendrimers (PAMAMs), which are intended to effectively bind to galectin-3, and thereby allow platinum-induced apoptosis. The target lactose functionalized PAMAM has been synthesized. ¹H NMR spectral data for synthetic intermediates for progress toward the target carbohydrate molecule confirm the success of the reaction pathway. Efficacy of the lactose functionalized PAMAMs is currently being tested in cell-based assays.en_US
dc.identifier.urihttps://scholars.carroll.edu/handle/20.500.12647/10556
dc.language.isoenen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.titleOptimization of Lactose-Functionalized Poly(amidoamine) Dendrimer Synthesisen_US
dc.typePresentationen_US
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