Optimization of Lactose-Functionalized Poly(amidoamine) Dendrimer Synthesis
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Authors
Field, Cameren
Advisor
Cloninger, Mary
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Date of Issue
2022
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Title
Optimization of Lactose-Functionalized Poly(amidoamine) Dendrimer Synthesis
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Abstract
Glycopolymers have been previously shown to regulate multivalent galectin-3 mediated processes in cancer progression including in vitro homotypic cancer cellular aggregation/tumor formation, cancer cellular migration, angiogenesis, proliferation, and apoptosis. The objective of this research is to develop multivalent synthetic frameworks that bind to galectin-3 and inhibit its anti-apoptotic biochemical pathway in SKOV-3 and OVCAR-3 ovarian cancer cell lines, thus preventing platinum chemotherapy agent resistance. Herein is the reported data for designing a high-yielding synthesis of lactose-functionalized poly(amidoamine) dendrimers (PAMAMs), which are intended to effectively bind to galectin-3, and thereby allow platinum-induced apoptosis. The target lactose functionalized PAMAM has been synthesized. ¹H NMR spectral data for synthetic intermediates for progress toward the target carbohydrate molecule confirm the success of the reaction pathway. Efficacy of the lactose functionalized PAMAMs is currently being tested in cell-based assays.
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Chemistry