Studies of Mosaicism for Chromosomal Aneuploidy in Fetal Loss Using Fluorescence In Situ Hybridization on Several Tissue Types

carrollscholars.legacy.contextkey11173028
carrollscholars.legacy.itemurlhttps://scholars.carroll.edu/lifesci_theses/102
carrollscholars.object.degreeBachelor's
carrollscholars.object.departmentLife & Environmental Sciences
carrollscholars.object.disciplinesBiochemistry; Life Sciences; Molecular Biology; Molecular Genetics
carrollscholars.object.seasonSpring
dc.contributor.advisorMarilyn Schendel
dc.contributor.advisorMary Haag
dc.contributor.advisorJohn Addis
dc.contributor.authorKnox, Aaron
dc.date.accessioned2020-04-30T10:00:37Z
dc.date.available2020-04-30T10:00:37Z
dc.date.embargo12/31/1899 0:00
dc.date.issued1999-04-01
dc.description.abstractThe main objective ofthis study was to determine the presence and level of mosaicism for chromosomal aneuploidy in several cases of fetal demise that had previous indications of chromosome aberrations. The presence of aneuploidy was determined using fluorescence in situ hybridization (FISH) probes. Techniques that were utilized in attempts to prepare several tissue types for FISH are described. The analyses made with FISH provided useful data on the chromosomal makeup oftwo of the cases studied. In one case FISH results showed that the product of conception (POC) did not contain the trisomy 18 that is present at low levels in the mother’s blood cells. In the other case the miscarried fetus was previously identified as being mosaic for trisomy X. In this research project the presence ofvarying levels of trisomy X in both embryonic and placental tissue was confirmed
dc.identifier.urihttps://scholars.carroll.edu/handle/20.500.12647/2842
dc.titleStudies of Mosaicism for Chromosomal Aneuploidy in Fetal Loss Using Fluorescence In Situ Hybridization on Several Tissue Types
dc.typethesis
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
1999_KnoxA_THS_000255.pdf
Size:
2.81 MB
Format:
Adobe Portable Document Format