Total Synthesis of 3-Oxyangeloyl-tremetone
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Authors
Deschamps, Natalee
Date of Issue
2023-04-28
Type
Presentation
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Abstract
Retrosynthetic analysis involves breaking a target molecule down into simpler structures to propose a synthetic pathway to its formation. This research project focuses on the retrosynthesis of a molecule with pharmaceutical applications. The compound of interest, 3-Oxyangeloyl-tremetone, has been extracted from a medicinal root in Chile and has shown analgesic activity (painkiller). Extraction from plants and other resources is often not feasible on a larger scale due to cost and logistics. The proposed five-step total synthesis of 3-Oxyangeloyl-tremetone utilizes inexpensive and readily available reagents. The first step of this synthesis has been completed and conditions to optimize the second step are currently underway.