Total Synthesis of 3-Oxyangeloyl-tremetone

No Thumbnail Available
Authors
Deschamps, Natalee
Advisor
Pharr, Caroline
Editor
Date of Issue
2023-04-28
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
Total Synthesis of 3-Oxyangeloyl-tremetone
Other Titles
Type
Presentation
Description
Abstract
Retrosynthetic analysis involves breaking a target molecule down into simpler structures to propose a synthetic pathway to its formation. This research project focuses on the retrosynthesis of a molecule with pharmaceutical applications. The compound of interest, 3-Oxyangeloyl-tremetone, has been extracted from a medicinal root in Chile and has shown analgesic activity (painkiller). Extraction from plants and other resources is often not feasible on a larger scale due to cost and logistics. The proposed five-step total synthesis of 3-Oxyangeloyl-tremetone utilizes inexpensive and readily available reagents. The first step of this synthesis has been completed and conditions to optimize the second step are currently underway.
Sponsors
Degree Awarded
Semester
Spring
Department
Chemistry