Investigating the Role of PrP and Amyloid Beta Proteins in AD and Other Protein-Misfolding Diseases

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Authors
Cornish, Steven
Advisor
Editor
Date of Issue
2015-04-01
Subject Keywords
Prion, Alzheimer's
Publisher
Citation
Series/Report No.
item.page.identifier
Title
Investigating the Role of PrP and Amyloid Beta Proteins in AD and Other Protein-Misfolding Diseases
Other Titles
Type
thesis
Description
Abstract
Prion diseases are very rare, neurodegenerative diseases caused by misfolding of the Prion protein. The pathologies created by the misfolded protein are remarkably similar to those of Alzheimer’s disease. This paper provides a comprehensive study of the genomic and proteomic similarities between Prion proteins and several proteins implicated in Alzheimer’s disease (AD). While genomic similarity has been proven, studies are unclear as to whether any genomic mutations in PRNP affect the progression of AD. Studies have definitively proven that Prion protein interacts on a molecular level with several proteins implicated in AD. These interactions require further study to definitively prove whether they speed or slow AD progression, but current evidence indicates that Prion protein interaction will lead to faster progression of AD in vitro.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences