A Study Of The Determinants On GP70, A Viral Envelope Glycoprotein, To Which Neutralizing Monoclonal Antibodies Bind

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Authors
Holland, Swend
Advisor
John Christenson
Guido Bugni
Joseph Ward
Editor
Date of Issue
1986-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
A Study Of The Determinants On GP70, A Viral Envelope Glycoprotein, To Which Neutralizing Monoclonal Antibodies Bind
Other Titles
Type
thesis
Description
Abstract
Lake Casitas Ecotropic virus causes a hind limb paralysis when injected into newborn mice. The long term goal is to select mutants of the virus using monoclonal antibodies and mutagens. Two of the monoclonal antibodies produced against this virus are neutralizing and also bind to the protein part of gp70, a viral envelope glycoprotein. Because of this, they can be used to select mutant viruses. There is no significant binding inhibition between monoclonal 704 and either of the two neutralizing monoclonals. Therefore, monoclonal 704 can be used in a focal-immuno-assay with the neutralizing monoclonals to locate mutant viruses.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences