Comparison of Prenatal and Postnatal Treatment of Myelomeningocele: A Systematic Review

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Authors
Gannon, Sydney
Advisor
Schafer, Gerald
Editor
Date of Issue
2024
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Title
Comparison of Prenatal and Postnatal Treatment of Myelomeningocele: A Systematic Review
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Presentation
Description
Abstract
Objective: To review relevant literature concerning the impact of prenatal repair of myelomeningocele on overall infant and maternal health, compared to postnatal repair of myelomeningocele. Methods: Literature was gathered through PubMed and CINAHL and assessed for long- and short-term effects of prenatal and postnatal repair of myelomeningocele on infant and maternal health. Results: Prenatal repair was associated with significant health and functionality improvements in later childhood compared to postnatal repair, but it was also correlated with increased pre-labor risks for both mother and child. Conclusions: While unique, individual features such as lesion size have an impact on the suggested treatment of myelomeningocele, current research suggests that prenatal repair is associated with more positive long-term health than postnatal repair; however, this treatment comes with the risk of complications in the pre-labor stages. The interventions mentioned in this review should be further researched to provide additional treatment options.
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Health Sciences