Identification of Key Binding Partners of Elongin C
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Authors
Maffit, Allie
Advisor
Sam Alvey
Ron Wilde
Murphy Fox
Ron Wilde
Murphy Fox
Editor
Date of Issue
2006-04-01
Subject Keywords
Elongin C, prostate, cancer
Publisher
Citation
Series/Report No.
item.page.identifier
Title
Identification of Key Binding Partners of Elongin C
Other Titles
Type
thesis
Description
Abstract
Cancer is the second leading cause of death in the United States. Prostate cancer affects one in seven men in the United States. Thus, prostate cancer provides a very serious healthy threat to men in the United States. Unfortunately, not much is known as to how normal prostate cells are transformed into a cancerous state, or how once transformed remain in the cancerous state. A study preformed by Porkka et. al in 2002 revealed that Elongin C is over expressed in prostate cancer cell lines. I hypothesize that over expression of Elongin C could inappropriately stabilize or destabilize key proteins involved in cell regulation leading to the mutation and or proliferation of cancerous cells. Through the use of a two-hybrid screening process I have identified four proteins within the prostate cell that interact with Elongin C.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences